Liver is largest internal organ of the human body. The liver, which is part of the digestive system, performs more than 500 different functions, all of which are essential to life.

The liver is a vital organ normally present in humans, in the upper right quadrant of the abdomen. The liver is necessary for survival, and there is currently no way to compensate for the absence of liver function in the long term, although new liver dialysis techniques can be used in the short term.

The liver is unique among the body’s vital organs in that it can regenerate, or grow back, cells that have been destroyed by some short-term injury or disease. But if the liver is damaged repeatedly over a long period of time, it may undergo irreversible changes that permanently interfere with function.

The largest internal organ in humans, the liver is also one of the most important.

Its essential functions include helping the body to digest fats, storing reserves of nutrients, filtering poisons and wastes from the blood, synthesizing a variety of proteins, immune and clotting factors, and oxygen and fat-carrying substances and regulating the levels of many chemicals found in the bloodstream.

Its chief digestive function is the secretion of bile, a solution critical to fat emulsion and absorption. The liver also removes excess glucose from circulation and stores it until it is needed. It converts excess amino acids into useful forms and filters drugs and poisons from the bloodstream, neutralizing them and excreting them in bile. The liver has two main lobes, located just under the diaphragm on the right side of the body. It can lose 75 percent of its tissue (to disease or surgery) without ceasing to function.

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